Substantia nigra neuromelanin magnetic resonance imaging in patients with different subtypes of Parkinson disease
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چکیده
منابع مشابه
Neuromelanin Magnetic Resonance Imaging Reveals Increased Dopaminergic Neuron Activity in the Substantia Nigra of Patients with Schizophrenia
PURPOSE The dopamine hypothesis suggests that excessive dopamine release results in the symptoms of schizophrenia. The purpose of this study was to elucidate the dopaminergic and noradrenergic neurons using 3-T neuromelanin magnetic resonance imaging (MRI) in patients with schizophrenia and healthy control subjects. METHODS We prospectively examined 52 patients with schizophrenia (M: F = 27∶2...
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BACKGROUND AND PURPOSE Visualizing with MR imaging and obtaining quantitative indexes of degeneration of the substantia nigra in Parkinson disease have been long-sought goals. We investigated the potential role of area and T1 contrast measurements in differentiating patients from controls and their age-related changes. METHODS Eight patients with Parkinson disease, 8 age-matched controls, and...
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Activation of the complement system promotes the removal of pathogens and tissue damage products from the brain and may also be involved in neuronal cell death in neurodegenerative diseases. Here, we analyzed the expression of C1q, the initial recognition subcomponent of the classic complement cascade, in the substantia nigra pars compacta (SNc) in Parkinson disease (PD) and control cases using...
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OBJECTIVE Mutations in the glucocerebrosidase gene (GBA) represent a significant risk factor for developing Parkinson disease (PD). We investigated the enzymatic activity of glucocerebrosidase (GCase) in PD brains carrying heterozygote GBA mutations (PD+GBA) and sporadic PD brains. METHODS GCase activity was measured using a fluorescent assay in cerebellum, frontal cortex, putamen, amygdala, ...
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ژورنال
عنوان ژورنال: Journal of Neural Transmission
سال: 2021
ISSN: 0300-9564,1435-1463
DOI: 10.1007/s00702-020-02295-8